Microfluidic NMR (微流控核磁)
Revealing the mechanism of molecular assembly require proper characterization methods. Because molecular assembly involves hierarchical, multi-sites, weak non-covalent interaction with synergy and feedbacks, characterization methods need to have high energy, spatial, and time resolution. Nuclear Magnetic Resonance (NMR) have high resolution in energy and spatial, but due to its poor sensitivity, the time resolution of NMR is poor, which makes it difficult to monitor assembly process. In collaboration with University of Southampton, we developed microfluidic NMR, bring the time resolution of NMR up to 1 s (both 1D and 2D NMR spectra). Moreover, the building blocks are mixed and assembled inside the microfluidic chip, enabling acquisition of NMR spectra after the assembly started in 1 s. Microfluidic NMR filled the shortcomings of NMR, making it suitable for monitoring process of molecular assembly and unraveling mechanism.
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